日韩福利-91看片网-狠狠撸视频-在线免费观看av网站-黄色在线视频观看-91高清免费-波多野结衣中文字幕在线播放-中文视频在线-国产香蕉网-国产在线1-中文字幕一二-丰满熟妇乱又伦-麻豆系列-六月婷婷中文字幕-欧美日a-伊人网伊人影院-五月天婷婷激情视频-国产精品二区视频-日欧美老女人-在线电影一区二区三区-wwwxxxx在线观看-国产免费无码一区二区视频-日本在线视频二区-色婷婷国产精品一区二区-免费视频一区二区三区四区

一.產品名稱：

通用名稱：大/小鼠成纖維細胞生長因子23 ELISA試劑盒

英文名稱：Mouse/Rat FGF-23 ELISA Kit

二.Mouse FGF-23 ELISA介紹：

Mouse/Rat FGF-23 ELISA Kit is intended for research use only in the quantitative determination of Mouse FGF-23 levels in serum, plasma or cell culture media. This assay is also useful in the determination of Rat FGF-23 levels.
 

Fibroblast growth factor 23 (FGF-23) is a recently discovered, novel member of a large family of related proteins. Its gene encodes a 251 amino acid protein. The amino-terminal portion of FGF-23 (aa 1-24) is hydrophobic and is likely to serve as a signal peptide allowing its secretion into the blood circulation. Its carboxyl-terminal portion (aa 180-251) shares only limited amino acid homology with other members of the FGF family of proteins.

Renal phosphate wasting disorders leading to hypophosphatemia are among the causes of defective mineralization of bone and growth plate development. Autosomal dominant hypophosphatemic rickets (ADHR), a rare genetic disorder, results from one of several different FGF-23 mutations that make the protein resistant to proteolytic cleavage. Furthermore, tumors that cause oncogenic osteomalacia (OOM) have been shown to overexpress FGF-23 mRNA making it likely that elevated concentrations of FGF-23 in the blood are the cause of renal phosphate wasting. Consistent with this conclusion, the administration of recombinant FGF-23 to rodents was shown to increase urinary excretion of phosphate thus leading to hypophosphatemia and osteomalacia/rickets. Recent studies with chronic kidney disease (CKD) patients have shown FGF-23 to be an early predictor of abnormal renal tubular function, bone mineralization, disease progression and over-all mortality risk.

Taken together, all currently available data suggest that the measurement of FGF-23 levels may provide an important diagnostic tool for the evaluation of hypophosphatemic and hyperphosphatemic disorders.
 

如需了解更多產品，請北京科瑞美公司。